Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella).
Identifieur interne : 000363 ( Main/Exploration ); précédent : 000362; suivant : 000364Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella).
Auteurs : Kai-Zhuo Wang [République populaire de Chine] ; Lin Feng [République populaire de Chine] ; Wei-Dan Jiang [République populaire de Chine] ; Pei Wu [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Jun Jiang [République populaire de Chine] ; Sheng-Yao Kuang [République populaire de Chine] ; Ling Tang [République populaire de Chine] ; Yong-An Zhang [République populaire de Chine] ; Xiao-Qiu Zhou [République populaire de Chine]Source :
- Fish & shellfish immunology [ 1095-9947 ] ; 2019.
Descripteurs français
- KwdFr :
- Aeromonas hydrophila (physiologie), Aliment pour animaux (analyse), Animaux (MeSH), Carpes (poisson) (MeSH), Compléments alimentaires (analyse), Gossypol (administration et posologie), Gossypol (analogues et dérivés), Gossypol (métabolisme), Immunité innée (effets des médicaments et des substances chimiques), Immunité innée (immunologie), Infections bactériennes à Gram négatif (immunologie), Infections bactériennes à Gram négatif (médecine vétérinaire), Inflammation (immunologie), Inflammation (induit chimiquement), Inflammation (médecine vétérinaire), Intestins (effets des médicaments et des substances chimiques), Intestins (immunologie), Maladies des poissons (immunologie), Maladies des poissons (induit chimiquement), Maladies des poissons (microbiologie), Relation dose-effet des médicaments (MeSH), Régime alimentaire (médecine vétérinaire), Répartition aléatoire (MeSH).
- MESH :
- administration et posologie : Gossypol.
- analogues et dérivés : Gossypol.
- analyse : Aliment pour animaux, Compléments alimentaires.
- effets des médicaments et des substances chimiques : Immunité innée, Intestins.
- immunologie : Immunité innée, Infections bactériennes à Gram négatif, Inflammation, Intestins, Maladies des poissons.
- induit chimiquement : Inflammation, Maladies des poissons.
- microbiologie : Maladies des poissons.
- médecine vétérinaire : Infections bactériennes à Gram négatif, Inflammation, Régime alimentaire.
- métabolisme : Gossypol.
- physiologie : Aeromonas hydrophila.
- Animaux, Carpes (poisson), Relation dose-effet des médicaments, Répartition aléatoire.
English descriptors
- KwdEn :
- Aeromonas hydrophila (physiology), Animal Feed (analysis), Animals (MeSH), Carps (MeSH), Diet (veterinary), Dietary Supplements (analysis), Dose-Response Relationship, Drug (MeSH), Fish Diseases (chemically induced), Fish Diseases (immunology), Fish Diseases (microbiology), Gossypol (administration & dosage), Gossypol (analogs & derivatives), Gossypol (metabolism), Gram-Negative Bacterial Infections (immunology), Gram-Negative Bacterial Infections (veterinary), Immunity, Innate (drug effects), Immunity, Innate (immunology), Inflammation (chemically induced), Inflammation (immunology), Inflammation (veterinary), Intestines (drug effects), Intestines (immunology), Random Allocation (MeSH).
- MESH :
- chemical , administration & dosage : Gossypol.
- chemical , analogs & derivatives : Gossypol.
- analysis : Animal Feed, Dietary Supplements.
- chemically induced : Fish Diseases, Inflammation.
- drug effects : Immunity, Innate, Intestines.
- immunology : Fish Diseases, Gram-Negative Bacterial Infections, Immunity, Innate, Inflammation, Intestines.
- chemical , metabolism : Gossypol.
- microbiology : Fish Diseases.
- physiology : Aeromonas hydrophila.
- veterinary : Diet, Gram-Negative Bacterial Infections, Inflammation.
- Animals, Carps, Dose-Response Relationship, Drug, Random Allocation.
Abstract
The present study explored the effects of dietary gossypol on the gut health of on-growing grass carp. The fish were fed six diets containing different levels of free gossypol (0, 121.38, 243.94, 363.89, 759.93 and 1162.06 mg/kg diet) from gossypol-acetic acid for 60 days and then challenged with Aeromonas hydrophila for 14 days. The results showed that dietary gossypol (1) could aggravate enteritis and damage the structure of intestinal epithelial cells, (2) decreased the lysozyme (LZ) and Acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents, and it down-regulated the Hepcidin (rather than distal intestine (DI)), immunoglobulin Z (IgZ), liver-expressed antimicrobial peptide (LEAP)-2B, Mucin2 and β-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and DI, (3) up-regulated intestinal pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interferon γ2 (IFN-γ2), interleukin 1β (IL-1β), IL-6 (only in PI), IL-8 and IL-12p35 mRNA levels partly related to nuclear factor kappa B (NF-κB) signalling, and (4) down-regulated the mRNA levels of anti-inflammatory cytokines such as transforming growth factor (TGF)-β1, TGF-β2, interleukin 4/13A (IL-4/13A) (except IL-4/13B), IL-10 and IL-11 partly relating to target of rapamycin (TOR) signalling in the intestines of on-growing grass carp. Moreover, the dietary gossypol had no impact on the LEAP-2A, IL-12P40, IL-17D, IL-10, NF-κBp52, IKKα and eIF4E-binding proteins 2 (4E-BP2) mRNA levels in the intestines. Finally, based on the intestinal histopathological results, enteritis morbidity, LZ activity and IgM content, the safe dose of gossypol in the diets for on-growing grass carp should be less than 103.42 mg/kg diet.
DOI: 10.1016/j.fsi.2018.12.014
PubMed: 30543935
Affiliations:
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Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China. 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Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130</wicri:regionArea><wicri:noRegion>611130</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Wei Dan" sort="Jiang, Wei Dan" uniqKey="Jiang W" first="Wei-Dan" last="Jiang">Wei-Dan Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130</wicri:regionArea><wicri:noRegion>611130</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130</wicri:regionArea><wicri:noRegion>611130</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130</wicri:regionArea><wicri:noRegion>611130</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Jun" sort="Jiang, Jun" uniqKey="Jiang J" first="Jun" last="Jiang">Jun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130</wicri:regionArea><wicri:noRegion>611130</wicri:noRegion></affiliation></author><author><name sortKey="Kuang, Sheng Yao" sort="Kuang, Sheng Yao" uniqKey="Kuang S" first="Sheng-Yao" last="Kuang">Sheng-Yao Kuang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu, 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu, 610066</wicri:regionArea><wicri:noRegion>610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu, 610066, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu, 610066</wicri:regionArea><wicri:noRegion>610066</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072</wicri:regionArea><wicri:noRegion>430072</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China. Electronic address: xqzhouqq@tom.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130</wicri:regionArea><wicri:noRegion>611130</wicri:noRegion></affiliation></author></analytic><series><title level="j">Fish & shellfish immunology</title><idno type="eISSN">1095-9947</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aeromonas hydrophila (physiology)</term><term>Animal Feed (analysis)</term><term>Animals (MeSH)</term><term>Carps (MeSH)</term><term>Diet (veterinary)</term><term>Dietary Supplements (analysis)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Fish Diseases (chemically induced)</term><term>Fish Diseases (immunology)</term><term>Fish Diseases (microbiology)</term><term>Gossypol (administration & dosage)</term><term>Gossypol (analogs & derivatives)</term><term>Gossypol (metabolism)</term><term>Gram-Negative Bacterial Infections (immunology)</term><term>Gram-Negative Bacterial Infections (veterinary)</term><term>Immunity, Innate (drug effects)</term><term>Immunity, Innate (immunology)</term><term>Inflammation (chemically induced)</term><term>Inflammation (immunology)</term><term>Inflammation (veterinary)</term><term>Intestines (drug effects)</term><term>Intestines (immunology)</term><term>Random Allocation (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aeromonas hydrophila (physiologie)</term><term>Aliment pour animaux (analyse)</term><term>Animaux (MeSH)</term><term>Carpes (poisson) (MeSH)</term><term>Compléments alimentaires (analyse)</term><term>Gossypol (administration et posologie)</term><term>Gossypol (analogues et dérivés)</term><term>Gossypol (métabolisme)</term><term>Immunité innée (effets des médicaments et des substances chimiques)</term><term>Immunité innée (immunologie)</term><term>Infections bactériennes à Gram négatif (immunologie)</term><term>Infections bactériennes à Gram négatif (médecine vétérinaire)</term><term>Inflammation (immunologie)</term><term>Inflammation (induit chimiquement)</term><term>Inflammation (médecine vétérinaire)</term><term>Intestins (effets des médicaments et des substances chimiques)</term><term>Intestins (immunologie)</term><term>Maladies des poissons (immunologie)</term><term>Maladies des poissons (induit chimiquement)</term><term>Maladies des poissons (microbiologie)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Régime alimentaire (médecine vétérinaire)</term><term>Répartition aléatoire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Gossypol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Gossypol</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Gossypol</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Gossypol</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Aliment pour animaux</term><term>Compléments alimentaires</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Animal Feed</term><term>Dietary Supplements</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Fish Diseases</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunity, Innate</term><term>Intestines</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Immunité innée</term><term>Intestins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité innée</term><term>Infections bactériennes à Gram négatif</term><term>Inflammation</term><term>Intestins</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Fish Diseases</term><term>Gram-Negative Bacterial Infections</term><term>Immunity, Innate</term><term>Inflammation</term><term>Intestines</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Inflammation</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Gossypol</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Fish Diseases</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections bactériennes à Gram négatif</term><term>Inflammation</term><term>Régime alimentaire</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Gossypol</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Aeromonas hydrophila</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aeromonas hydrophila</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Diet</term><term>Gram-Negative Bacterial Infections</term><term>Inflammation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Carps</term><term>Dose-Response Relationship, Drug</term><term>Random Allocation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Carpes (poisson)</term><term>Relation dose-effet des médicaments</term><term>Répartition aléatoire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study explored the effects of dietary gossypol on the gut health of on-growing grass carp. The fish were fed six diets containing different levels of free gossypol (0, 121.38, 243.94, 363.89, 759.93 and 1162.06 mg/kg diet) from gossypol-acetic acid for 60 days and then challenged with Aeromonas hydrophila for 14 days. The results showed that dietary gossypol (1) could aggravate enteritis and damage the structure of intestinal epithelial cells, (2) decreased the lysozyme (LZ) and Acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents, and it down-regulated the Hepcidin (rather than distal intestine (DI)), immunoglobulin Z (IgZ), liver-expressed antimicrobial peptide (LEAP)-2B, Mucin2 and β-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and DI, (3) up-regulated intestinal pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interferon γ2 (IFN-γ2), interleukin 1β (IL-1β), IL-6 (only in PI), IL-8 and IL-12p35 mRNA levels partly related to nuclear factor kappa B (NF-κB) signalling, and (4) down-regulated the mRNA levels of anti-inflammatory cytokines such as transforming growth factor (TGF)-β1, TGF-β2, interleukin 4/13A (IL-4/13A) (except IL-4/13B), IL-10 and IL-11 partly relating to target of rapamycin (TOR) signalling in the intestines of on-growing grass carp. Moreover, the dietary gossypol had no impact on the LEAP-2A, IL-12P40, IL-17D, IL-10, NF-κBp52, IKKα and eIF4E-binding proteins 2 (4E-BP2) mRNA levels in the intestines. Finally, based on the intestinal histopathological results, enteritis morbidity, LZ activity and IgM content, the safe dose of gossypol in the diets for on-growing grass carp should be less than 103.42 mg/kg diet.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30543935</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>23</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9947</ISSN><JournalIssue CitedMedium="Internet"><Volume>86</Volume><PubDate><Year>2019</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Fish & shellfish immunology</Title><ISOAbbreviation>Fish Shellfish Immunol</ISOAbbreviation></Journal><ArticleTitle>Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella).</ArticleTitle><Pagination><MedlinePgn>814-831</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1050-4648(18)30813-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fsi.2018.12.014</ELocationID><Abstract><AbstractText>The present study explored the effects of dietary gossypol on the gut health of on-growing grass carp. The fish were fed six diets containing different levels of free gossypol (0, 121.38, 243.94, 363.89, 759.93 and 1162.06 mg/kg diet) from gossypol-acetic acid for 60 days and then challenged with Aeromonas hydrophila for 14 days. The results showed that dietary gossypol (1) could aggravate enteritis and damage the structure of intestinal epithelial cells, (2) decreased the lysozyme (LZ) and Acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents, and it down-regulated the Hepcidin (rather than distal intestine (DI)), immunoglobulin Z (IgZ), liver-expressed antimicrobial peptide (LEAP)-2B, Mucin2 and β-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and DI, (3) up-regulated intestinal pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interferon γ2 (IFN-γ2), interleukin 1β (IL-1β), IL-6 (only in PI), IL-8 and IL-12p35 mRNA levels partly related to nuclear factor kappa B (NF-κB) signalling, and (4) down-regulated the mRNA levels of anti-inflammatory cytokines such as transforming growth factor (TGF)-β1, TGF-β2, interleukin 4/13A (IL-4/13A) (except IL-4/13B), IL-10 and IL-11 partly relating to target of rapamycin (TOR) signalling in the intestines of on-growing grass carp. Moreover, the dietary gossypol had no impact on the LEAP-2A, IL-12P40, IL-17D, IL-10, NF-κBp52, IKKα and eIF4E-binding proteins 2 (4E-BP2) mRNA levels in the intestines. Finally, based on the intestinal histopathological results, enteritis morbidity, LZ activity and IgM content, the safe dose of gossypol in the diets for on-growing grass carp should be less than 103.42 mg/kg diet.</AbstractText><CopyrightInformation>Copyright © 2018. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Kai-Zhuo</ForeName><Initials>KZ</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Wei-Dan</ForeName><Initials>WD</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Pei</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuang</LastName><ForeName>Sheng-Yao</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu, 610066, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Academy of Animal Science, Chengdu, 610066, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yong-An</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Xiao-Qiu</ForeName><Initials>XQ</Initials><AffiliationInfo><Affiliation>Animal Nutrition Institute, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Sichuan, Chengdu, 611130, China; Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan, Agricultural University, Sichuan, Chengdu, 611130, China. Electronic address: xqzhouqq@tom.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Fish Shellfish Immunol</MedlineTA><NlmUniqueID>9505220</NlmUniqueID><ISSNLinking>1050-4648</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>KAV15B369O</RegistryNumber><NameOfSubstance UI="D006072">Gossypol</NameOfSubstance></Chemical><Chemical><RegistryNumber>S7RL72610R</RegistryNumber><NameOfSubstance UI="C028178">gossypol acetic acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016980" MajorTopicYN="N">Aeromonas hydrophila</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000821" MajorTopicYN="N">Animal Feed</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002347" MajorTopicYN="Y">Carps</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019587" MajorTopicYN="N">Dietary Supplements</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005393" MajorTopicYN="N">Fish Diseases</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006072" MajorTopicYN="N">Gossypol</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016905" MajorTopicYN="N">Gram-Negative Bacterial Infections</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gossypol</Keyword><Keyword MajorTopicYN="N">Grass carp (Ctenopharyngodon idella)</Keyword><Keyword MajorTopicYN="N">Intestinal immunity</Keyword><Keyword MajorTopicYN="N">NF-κB signalling</Keyword><Keyword MajorTopicYN="N">TOR signalling</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>11</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>12</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>5</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>12</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30543935</ArticleId><ArticleId IdType="pii">S1050-4648(18)30813-1</ArticleId><ArticleId IdType="doi">10.1016/j.fsi.2018.12.014</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Kai Zhuo" sort="Wang, Kai Zhuo" uniqKey="Wang K" first="Kai-Zhuo" last="Wang">Kai-Zhuo Wang</name></noRegion><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><name sortKey="Jiang, Jun" sort="Jiang, Jun" uniqKey="Jiang J" first="Jun" last="Jiang">Jun Jiang</name><name sortKey="Jiang, Wei Dan" sort="Jiang, Wei Dan" uniqKey="Jiang W" first="Wei-Dan" last="Jiang">Wei-Dan Jiang</name><name sortKey="Kuang, Sheng Yao" sort="Kuang, Sheng Yao" uniqKey="Kuang S" first="Sheng-Yao" last="Kuang">Sheng-Yao Kuang</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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